A law enforcement officer said three people were killed inside a vehicle on the street and four were wounded outside, in the Benedict Canyon area.
The wounded have been taken to local hospitals and are in critical condition.
California Mass Shooting: 72-year-old suspect Huu Can Tran kills self as police surround him
Los Angeles Fire Department officials said the shooting was reported around 2.30am (local time). Sgt. Frank Preciado of the Los Angeles Police Department said the identities of the victims are being confirmed.
The shooting comes just a week after 11 people were killed in a mass shooting at a dance hall in Monterey Park. Three days days after that, a gunman killed seven people at two farms around Half Moon Bay.
(This is a developing story)